pentobarbital will decrease the level or effect of diazepam buccal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. Powerful or average CYP3A4 inducers might raise rate of diazepam elimination; hence, efficacy of diazepam could be lowered.
pentobarbital will lower the extent or influence of buprenorphine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.
Caution when discontinuing CYP3A4 inducers which are coadministered with hydrocodone; plasma concentrations of hydrocodone may perhaps boost and can result in most likely fatal respiratory depression
Caution when discontinuing CYP3A4 inducers which can be coadministered with benzhydrocodone (prodrug of hydrocodone); plasma concentrations of hydrocodone might maximize and may end up in probably fatal respiratory melancholy.
pentobarbital decreases amounts of vandetanib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Avoid coadministration with powerful CYP3A4 inducers; these drugs reduce publicity to vandetanib by approximately forty%.
pentobarbital will decrease the extent or effect of ethinylestradiol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. The efficacy of hormonal contraceptives could be lowered. Use of a nonhormonal contraceptive is usually recommended.
Keep away from; coadministration with CYP3A inducers may perhaps result in reduced plasma concentrations of elvitegravir and/or possibly a concomitantly administered protease inhibitor and bring on lack of therapeutic outcome and also to doable resistance
pentobarbital will lower the extent or impact of montelukast by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Unidentified.
pentobarbital will lessen the level or influence of cyclosporine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
pentobarbital will reduce the level or result of etoposide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.
Check Intently (1)pentobarbital will decrease the extent or impact of hydrocodone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Closely. Warning when discontinuing CYP3A4 inducers that happen to be coadministered with hydrocodone; plasma concentrations of hydrocodone may possibly improve and may result in perhaps fatal respiratory depressionSerious - get more info Use Choice (1)hydrocodone, pentobarbital.
pentobarbital will lessen the level or effect of ondansetron by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. No dosage adjustment for ondansetron is recommended for people on these drugs.
Untimely infants are notably at risk of the depressant effects of barbiturates; if barbiturates are applied all through labor and supply, resuscitation machines need to be available
Contraindicated (1)pentobarbital decreases amounts of vandetanib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Stay away from coadministration with strong CYP3A4 inducers; these drugs minimize exposure to vandetanib by nearly 40%.